Preparation of 2-alkoxy-5-methoxybenzaldehydes and 2-ethoxy-5-alkoxybenzaldehydes
نویسندگان
چکیده
منابع مشابه
BILIARY EXCRETION AND BLOOD/PLASMA RATIO OF NOVEL 5-BROMO-6-ALKOXY-5,6-DIHYDRO PRODRUGS OF 5-ETHYL-2\'-DEOXYVRIDINE
The biliary excretion and blood/plasma ratios of four novel 5-bromo-6-alkoxy- 5,6-dihydro prodrugs to S-ethyl-2'-deoxyuridine (EDU) including (-)-trans-(5S, 6S)-S-bromo-S-ethyl-6-methoxy-S, 6-dihydro-2'-deoxyuridine (BMEDU), (+ )-trans( SR, 6R)-S-bromo-S-ethyl-6-ethoxy-S, 6-deoxyuridine (BEEDU), (+ )-trans-(SR, 6R)-5-bromo-5-ethyl-6-ethoxy -S, 6-dihydro-S '-O-valeryl-2 ':.deoxyuridine (VBE...
متن کاملEvaluation of (5R,6R)-5-Bromo-6-Ethoxy-5-Ethyl-5,6-Dihydro-2\'- Deoxyuridine as a Brain-Targeted Prodrug of 5-Ethyl-2\'- Deoxyuridine
(+)-Trans-(5R,6R)-5-bromo-6-ethoxy-5-ethyl-5,6-dihydro-2'-deoxyuridine [(5R,6R)-BEEDU], a potential brain-targeted prodrug of 5-ethyl-2'-deoxyuridine (EDU), was synthesized by the regiospecific addition of BrOEt to the 5,6-olefinic bond of EDU. (5R,6R)-BEEDU is more lipophilic (log P = 0.04) than EDU (log P = -1.09). In vitro incubation of (5R,6R)-BEEDU with rat whole blood and brain homogena...
متن کاملCyclization of 5-hexynoic acid to 3-alkoxy-2-cyclohexenones
The one-pot cyclization of 5-hexynoic acid to produce 3-alkoxy-2-cyclohexenones proceeds in good yields (58-90%). 3-Hexynoic acid was converted to its acyl chloride with the aid of oxalyl chloride and was cyclized to 3-chloro-2-cyclohexenone upon addition of indium(III) chloride. Subsequent addition of alcohol nucleophiles led to the desired 3-alkoxy-2-cyclohexenones.
متن کاملevaluation of (5r,6r)-5-bromo-6-ethoxy-5-ethyl-5,6-dihydro-2'- deoxyuridine as a brain-targeted prodrug of 5-ethyl-2'- deoxyuridine
(+)-trans-(5r,6r)-5-bromo-6-ethoxy-5-ethyl-5,6-dihydro-2'-deoxyuridine [(5r,6r)-beedu], a po tential brain-targeted prodrug of 5-ethyl-2'-deoxyuridine (edu), was synthesized by the regiospecific addition of broet to the 5,6-olefinic bond of edu. (5r,6r)-beedu is more lipophilic (log p = 0.04) than edu (log p = -1.09). in vitro incubation of (5r,6r)-beedu with rat whole blood and brain...
متن کاملPreparation of the individual diastereomers of adenylyl-(2'-5')-P-thioadenylyl-(2'-5')-adenosine and their 5'-phosphorylated derivatives.
The individual diastereomers of trimer A2'p5'A2'p(s)5'A, containing one phosphorothioate linkage, were prepared via a modified hydroxybenzotriazole phosphotriester approach. The 5'-phosphorylated derivatives of the latter compounds were obtained after phosphorylation with a 6-trifluoromethyl-1-benzotriazolyl activated phosphoromorpholidate.
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2000
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0001.603